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3 years ago in Molecular Biology , Systems Biology By Andrewenawn

How does systems biology explain the central dogma of molecular biology?

In my systems biology readings, the emphasis on networks, feedback loops, and emergent properties seems at odds with the simpler, directional dogma I learned in introductory courses. As I build computational models, I need to reconcile these views to accurately represent biological reality. How do modern systems thinkers conceptually frame this foundational rule?

Networks CentralDogma

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By Address@gmail.com Answered 3 years ago

Systems biology doesn't invalidate the Central Dogma; it embeds it within a vastly more complex regulatory landscape. From my work modeling gene networks, the dogma's core chemical pathway (DNA→RNA→protein) remains true. However, systems biology reframes it as one component in a dynamic, interconnected web. I have seen how feedback loops where proteins influence the expression of their own or other genes create non-linear causality. The "information flow" becomes multi-directional when you account for regulatory networks, epigenetic modifications, and signaling pathways that constantly modulate the dogma's basic process. It transforms from a simple pipeline into a dense, regulated circuit.

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